张丽娜,荷兰瓦格宁根大学博士、美国北卡莱罗纳大学博士后,江南大学食品学院副研究员。主要围绕乳中功能组分结构解析、加工特性、营养健康功效、分离制备及高值化应用等方面开展研究。主持承担国家自然科学基金面上基金、国家自然科学基金青年基金,十三五及十四五国家重点研发计划子课题等国家级及省部级项目6项;主持百万级校企合作项目3项;被评为江苏省“双创博士”;入选国际乳品协会中国委员会首届“优秀乳业科技工作者”;入选中国食品科学技术学会“未来科学领袖计划”。发表文章60余篇,授权专利6项。兼任中国畜产品青年委员协会委员、江苏省营养学会食品营养与特殊食品委员兼秘书。担任《Journal of Food Science and Animal Products》和《Journal of Future Foods》青年编委,《中国乳品工业》青年副主任委员,《Foods》客座编辑。
1.国家自然科学面上基金,基于N-糖修饰异质性解析乳铁蛋白抗消化结构及完整吸收特性机制研究,(32372246), 2014.01-2027.12,课题负责人,50万
2.十四五国家重点研发计划重点专项“基于中国母乳研究的新一代婴配乳粉制造技术研究及示范”子任务“基于低热结合非热杀菌技术及新型浓缩工艺开发高活性低能耗婴配粉的创新工艺研究”(2022YFD2101504)2022.12.1-2027.10.30,100万
3.外国高端专家引进计划项目“妊娠糖尿病母乳组分对婴幼儿肠道菌群及代谢的影响”(G2022144004L),2021.1-2023.12,课题负责人,11万
4.十三五国家重点研发计划“食品过敏标识的风险评估技术研究”项目子任务一“重要食物致敏原蛋白免疫交叉反应及致敏性评价体系研究”(2019YFC1605002),2019. 12-2022.12,83万
5.国家自然科学青年基金,糖基化在调控羊乳脂肪球膜蛋白热稳定性中的作用及机制, 31801463, 2019.01-2021.12,课题负责人,20万
6.江苏省自然科学基金青年基金,糖基化影响羊乳脂肪球膜蛋白热稳定性的机理,BK20180612, 2018.07-2020.06,课题负责人,20万
7.企业横向项目,山羊乳乳铁蛋白的结构及功能活性的研究,180万
8.企业横向项目,乳铁蛋白的体外消化吸收特性及抑菌作用研究,185万
9.企业横向项目,强化OPO、乳铁蛋白、CPP对婴配粉蛋白脂肪消化吸收特性以及促矿物质吸收的影响,165万
1.Mengyu Han, Xuemin Wang, Kai Zhang, Ignatius Man-Yau Szeto, Sufang Duan, Yalu Yan, Biao Liu, Kasper Hettinga,Lina Zhang*, Peng Zhou. How α-lactalbumin and β-casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model.Food Bioscience. 2024, 59, 103948.
2.Hongyang Han#, Jingjing Pei#, Jianhui Feng, Huifang Yao, Binsong Han, Yanmei Hou, Kui Xie, Jinjing Zhong,Lina Zhang*, Kasper Hettinga and Peng Zhou. Comparison of glycation and glycosylation level between bovine milk-based and goat milk-based infant formula through label-free proteomics techniques.Food Bioscience.2024, 59: 103857.
3.Yiqian Zhang,Lina Zhang*, Siquan Xia, Yanmei Hou, Tong Wu, Peng Zhou. Site-specific glycoproteomic analysis of purified lactoferrin from human and animal milk.International Journal of Biological Macromolecules. 2024, 254:127766.
4.Siquan Xia,Lina Zhang*, Yiqian Zhang, Hongyang Han, Yanmei Hou, Tong Wu, Peng Zhou. Structural characteristics and thermal stabilities of bovine, caprine and ovine lactoferrins with different iron saturation levels.Food Bioscience. 2023, 56:103275.
5.Lina Zhang, Qiaran Lin, Jinyue Zhang, Yue Shi, Lina Pan, Yanmei Hou, Xiaoyu Peng, Wei Li, Jiaqi Wang, and Peng Zhou*. Qualitative and quantitative changes of oligosaccharides in human and animal milk over lactation.Journal of Agricultural and Food Chemistry.2023, 71(42):15553-15568.封面
6.Tong Liu,Jianhui Feng,Hongyang Han,Jialu Huang,Lina Zhang*, Kasper Hettinga,Peng Zhou. Anti-inflammatory effects of dietary β-caseins peptide and its peptide QEPVL in a DSS-induced inflammatory bowel disease mouse model.Food Bioscience. 2023, 56:103375.
7.Binsong Han,Lina Zhang*,Ying Ma, Yanmei Hou, Kui Xie, Jingjing Zhong and Peng Zhou. Quantitative phosphoproteome of infant formula: New insights into the difference of phosphorylation in milk proteins between bovine and goat specie.Journal of Agricultural and Food Chemistry. 2023, 71, 3531−3540.封面
8.Lina Zhang, Ruoya Zhou, Kai Zhang, Peng Zhou*.Antigen presentation induced variation in ovalbumin sensitization between chicken and duck species.Food & Function. 2023, 14, 445.
9.Kai Zhang,Lina Zhang,*Ruoya Zhou, Jinjing Zhong, Kui Xie, Yanmei Hou and Peng Zhou. Cow’s milk αS1-casein is more sensitizing than goat’s milk αS1-casein in a mouse model.Food&Function. 2022, 13, 6484. 2022年6月22日.封面
10.Jianhui Feng,Lina Zhang*, Xue Tang, Wei Hu, Peng Zhou* Major yolk protein from sea cucumber (Stichopus japonicus) attenuates acute colitis via regulation of microbial dysbiosis and inflammatory responses.Food Research International, 2022, 51: 1108411.
11.Bingsong Han,Lina Zhang*, Baolong Luo, Yongqing Ni, Nidhi Bansal, Peng Zhou*Comparison of milk fat globule membrane and whey proteome between Dromedary and Bactrian camel.Food Chemistry. 2022, 367: 130658.
12.Yue Shi, Binsong Han,Lina Zhang*, Peng Zhou. Comprehensive identification and absolute quantification of milk oligosaccharides in different species.Journal of Agricultural and Food Chemistry. 2021 Dec 29; 69(51):15585-15597.
13.Lina Zhang,Jinyue Zhang, Binsong Han, Chen Chen, Jun Liu, Zhaona Sun, Min Liu, Peng Zhou*.Gestational Diabetes Mellitus induced Changes in Proteome and Glycated /Glycosylated Proteome of Human Colostrum.Journal of Agricultural and Food Chemistry.2021, 69(36):10749-10759.
14.Jingyan Qu,Lina Zhang*, Li’ ang Yin, Jun Liu, Zhaona Sun, Peng Zhou*.Changes in bioactive proteins and serum proteome of human milk under different frozen storage.Food Chemistry. 2021, 352:129436.
15.Ying Ma, Yanmei Hou, Binsong Han, Kui Xie,Lina Zhang*and Peng Zhou*. Peptidome comparison following gastrointestinal digesta of bovine versus caprine milk serum.Journal of Dairy Science. 2021, 104: 1-14.
16.Binsong Han, Yaqiong Jian, Xubin Xia, Wei Hu,Lina Zhang* and Peng Zhou. Studying the effects of sea cucumber ovum powder on nonalcoholic fatty liver disease by proteomics techniques in a rat model.Food&Function. 2020,11, 6139-6147.
17.Lina Zhang, Ying Ma, Zhenyu Yang, Shan Jiang, Jun Liu, Kasper A. Hettinga, Jianqiang Lai, Peng Zhou. Geography and ethnicity related variation in the Chinese human milk serum proteome.Food & Function. 2019, 10: 7818-7827. Ying Ma,Lina Zhang*, Yanyan Wu, Peng Zhou*. Changes in milk fat globule membrane proteome after pasteurization in human, bovine and caprine species.Food Chemistry. 2019, 279: 209–215.
18.Lina Zhang, Chih-Wei Liu, and Qibin Zhang. Online 2D-LC-MS/MS Platform for Analysis of Glycated Proteome.Analytical Chemistry. 2018, 90, 1081-1086.
1.周鹏;张丽娜;施悦;刘小鸣;刘要卫;刘大松.3’-唾液酸乳糖在制备缓解食物过敏的功能性食品中的应用. 中国发明专利. 2023. ZL2022106570709.
2.周鹏;冯建慧;张丽娜. 海参卵黄蛋白在制备缓解结肠炎的功能性食品中的应用. 中国发明专利. 2023. ZL202111227117.X
3.周鹏;冯建慧;张丽娜. 三步沉淀提取海参体壁主要卵黄蛋白的方法.中国发明专利. 2022. ZL202011518164.5
4.周鹏;张凯;张丽娜. 一种分离as1-酪蛋白的方法. 中国发明专利. 2022. ZL 202110292593.3
5.周鹏;张凯;张丽娜.A method foras1-casein separation.国际发明专利. 2022. 20220923145836717
6.罗永康,张丽娜. 一种快速无损伤检测淡水鱼鲜度的方法. 中国发明专利. ZL201005250008671.0