马朝阳,食品科学与工程专业工学博士,江南大学食品学院副研究员、硕士生导师。长期从事药食同源活性组分高效制备、生物转化、构效关系、计算化学、功能评价及功能食品与保健食品开发研究,具有10年保健食品研发与申报经验。近年来重点将人工智能、机器学习、虚拟筛选、分子对接和分子动力学模拟应用于天然活性组分的高通量筛选、活性预测及作用机制解析,逐步形成“AI/计算筛选-活性组分发现-高效制备与结构改造-AI赋能功能评价-功能食品开发”的研究体系。已发表论文30余篇,其中SCI论文20篇,授权发明专利4项。主持国家自然科学基金面上项目1项、科技部国家科技计划子课题2项及其他科研项目多项,具备较好的AI赋能天然活性物质发现及功能食品研发基础。
【学习经历】
1991–1995 郑州粮食学院 学士
2001–2004 江南大学 硕士
2004–2009 江南大学 博士
【工作经历】
1995–2001 潍坊市坊子区粮食局
2009–2013 江南大学食品学院 工程师
2013–2022 江南大学食品学院 高级工程师
2022–至今 江南大学食品学院 副研究员
【研究方向】
人工智能辅助食品功能因子发现;药食同源活性组分高效制备与生物转化;计算化学与构效关系;糖脂代谢功能评价;基于AI功能食品精准设计与开发。
1. 国家自然科学基金面上项目基于多尺度计算化学方法高通量虚拟筛选催化茶叶EGCG酯化反应立体选择性酶和底物与催化机理研究, 主持,2022–2025。
2. 科技部“十四五”国家科技计划项目子课题电商方便食品风险侦测、溯源及控制关键技术研究, 主持,2024–2028。
3. 科技部“十二五”国家科技计划子课题脂溶性EGCG制备、构效及检测技术, 主持,2014–2018。
4. 中央高校基本科研业务费专项基金营养代谢组学研究玫瑰红景天植物化学代谢指纹与抗疲劳活性的相关性及作用机制主持,2010–2011。
[1] Wang Shan, Ma Chaoyang*, Wang Hongxin. Effect of acyl donors on EGCG esterification reaction catalyzed by Lipase “Amano” 30SD based on molecular dynamics analysis[J]. Current Research in Food Science, 2026, 12:101277.
[2] Wang Shan, Li Yvbing, Wang Xinyue, Shan Liang, Wang Hongxin, Ma Chaoyang*. Computational Insights into the Selectivity of Lipases in the (−)-Epigallocatechin Gallate (EGCG) Esterification Reaction Based on Molecular Docking[J]. ACS OMEGA, 2026, 11(5):8172-8182.
[3]Ma Chaoyang*, Song Deao, Chen Jinghui. Integrating spectroscopic techniques and molecular dynamics simulations to probe the interaction between hesperidin and soy protein isolate and the consequent functional improvements[J]. Food Chemistry, 2025, 505:147947.
[4] Wang Xinyue, Tan Yeexuan, Li Yubing, Hongwei Tao, HongxinWang, Ma Chaoyang*. Spectroscopy and Computational Analysis of β-Lactoglobulin Interactions With Catechin: A Comparative Study of Single, Double,and Triple Catechin Complexes[J]. Journal of Food Science, 2025, 90(9):e70510.
[5] Chen Jinghui, Ge Weiben, Wang Yu, Hu Zan, Lv Wenping, Ma Chaoyang*, Wang Hongxin*. Controlled hydrolysis and EGCG conjugation enhance the ADH/ ALDH activation activity of chia seed meal protein hydrolysates: Fabrication and structural characterization[J]. Food Chemistry, 2025, 476:143386.
[6] Hu Zan, Wang Yu, Yu Dawei, Ma Chaoyang*. Novel analytical strategy integrating enzymatic hydrolysis with UPLC-MS/MS for precise quantification of free and bound heterocyclic aromatic amines in crispy fried pork[J]. Food Chemistry, 2025, 489:145020.
[7] Li Yubing, Wang Xinyue, Sun Haixun, Wang Hongxin, Ma Chaoyang*. Cheminformatics Exploration of Structural Physicochemical Properties, Molecular Fingerprinting, and Diversity of the Chemical Space of Compounds from Betel Nut (Areca catechu L.)[J]. ACS Omega, 2025, 10:1551−1561.
[8]Ma Chaoyang*, Zhou Xincheng, Yu Hairui, Ni Jian, Wang Xinyue, Li Yubing, Wang HongXin. Virtual screening and multi synergism of inhibitory compounds against pancreatic lipase [J]. Food Bioscience, 2024, 57:103601.
[9] Wang Shan, Jiang Chao, Jing Huijuan, Du Xiaojing, Zhu Song, Wang Hongxin, Ma Chaoyang*.Synthesis of ECG epicatechin gallate) acylated derivatives as new inhibitors of α amylase and their mechanism on delaying starch digestion [J]. Food Bioscience, 2023, 52:102466.
[10] Wang Shan, Mo Ling, Wu Beiqi, Ma Chaoyang*, Wang Hongxin*. Effect of structural stability of lipase in acetonitrile on its catalytic activity in EGCG esterification reaction: FTIR and MD simulation [J]. International journal of biological macromolecules, 2023, 255:128266.
[11] Chen Yu, Jing Huijuan, Du Xiaojing, Jiang Chengyu, Wang Li, Jiang Chao, Wang Hongxin, Ma Chaoyang*. Investigation on physicochemical, structural, and functional properties of protein from pecan (Carya illinoinensis (wangenh.) K. Koch) treated by three different peeling methods [J]. Journal of Food Measurement and Characterization, 2022,16 (5): 3512-3525.
[12] Jiang Chao, Chen Yu, Ye Xin, Wang Li, Shao Jiajia, Jing Huijuan, Jiang Chengyu, Wang, Hongxin, Ma, Chaoyang*. Three flavanols delay starch digestion by inhibiting alpha amylase and binding with starch [J], International journal of biological macromolecules, 2020, 172: 503-514.
[1] 马朝阳 (3/10); 茶叶功能性成分提取加工关键技术及其工业化应用, 中国商业联合会, 其他, 其他, 2013(王洪新; 娄在祥; 马朝阳; 朱松; 唐弟康; 李永仙; 兰海崇; 吕文平; 谭吉良; 余祖凤 )
[2] 马朝阳 (9/11); 药食同源植物功能成分提取精制关键技术研发与产业化应用 , 中国商业联合会, 其他, 其他, 2022(娄在祥; 成向容; 王洪新; 杨珂; 饶胜其; 於洪建; 吴仁觅; 兰海崇; 马朝阳; 吕文平; 许小鹏 )
[1] 黄鑫; 王洪新; 马朝阳; 娄在祥; 吕文平; 陈静钰; 王力. 氨基改性硅胶材料脱除水溶性茶提取物中种金属的方法, 2021 03 02, 中国, ZL201910191831.7 (专利 )
[2] 黄鑫; 王洪新; 马朝阳; 王力; 娄在祥; 陈静钰; 吕文平. 碱性氨基酸改性硅胶材料及其制备方法和应用, 2021 08 10, 中国, ZL201910191917.7 (专利 )
[3] 王洪新; 朱松; 李哲; 马朝阳; 一种用微波辅助脂肪酶催化合成酯化改性, 2014 02 19, 中国, ZL201210264118.6 (专利 )