承担科研项目：

1.“十四五”国家重点研发计划青年科学家项目，植物基人造肉中风险因子毒性可视化精准筛查与传感检测关键技术研究(2022YFF1103000)，主持

2.江苏省杰出青年基金项目，食品危害物适配体理性设计与多模式传感检测机制研究(BK20240100)，主持

3.中国科协“2017-2019年度青年人才托举工程”，粮油制品质量安全控制技术研究(2017QNRC001)，主持

4.国家自然科学基金（面上项目），基于深度学习辅助细胞内多种microRNAs荧光成像的真菌毒素联合毒性评价研究(32572707)，主持

5.国家自然科学基金（面上项目），基于适配体荧光纳米探针的呕吐毒素细胞毒性成像分析研究(32072310)，主持

6.国家自然科学基金（面上项目），上转换-二氧化钛红外光催化降解呕吐毒素作用机理及产物安全性评价研究(31772086)，主持

7.国家自然科学基金（青年项目），基于增敏型上转换荧光纳米探针的微生物毒素检测新方法研究(31401576)，主持

8.国家科技支撑计划子课题，水产品加工过程中安全危害的现场识别与检测技术(2015BAD17B02)，主持

9.江苏省重点研发计划项目（现代农业），农产品品质与安全智能检测关键共性技术研发(BE2016306)，主持

10.江苏省农业科技自主创新资金项目，食用农产品安全典型危害物高效识别与控制技术创新与集成应用(CX(18)2025-01)，主持

11.岭南现代农业科学与技术广东省实验室，水产品中禁用药物的前处理及智能传感检测关键技术研究(NZ2021037)，主持

12.新疆兵团重点领域科技攻关计划，基于适配体的奶牛早孕低成本快速检测技术研发与推广应用(2023AB009-01)，参与

13.广州市科技计划项目，基于适配体识别传感的食品危害物检测平台及监控系统开发(202206010096)，参与

14.中国博士后科学基金第九批特别资助，基于适配体识别的多种食源性致病菌快速检测技术研究(2016T90430)，主持

15.中国博士后科学基金面上一等，基于适配体识别上转换荧光标记的检测试纸条设计研究(2015M580402)，主持

16.江苏省博士后科研资助计划，基于适配体识别的食源性致病菌可视化检测技术研究(1601087B)，主持

17.江苏省科技支撑计划子课题，农产品与食品中真菌毒素三联快速检测试纸的关键技术开发及产业化示范(BE2013732)，主持

18.江苏检验检疫局项目，基于ZnS:Mn量子点标记的沙门氏菌快速检测新方法研究(2018KJ35)，参与

19.江南大学自主科研计划，新型纳米材料在生物毒素标记检测及光催化降解中的应用研究(JUSRP11436)，主持

20.基于多维度响应的葡萄酒真伪及品质鉴定共性技术平台开发，横向课题

21.食品中危害物检测与功能因子挖掘评估，横向课题

22.婴幼儿食品中危害物的检测技术研究，横向课题

23.大米新鲜度快速测定，横向课题

24.食品检测中样品前处理净化富集技术开发，横向课题

25.生物可降解垃圾解决方案的研发与安全性控制，横向课题

26.叶酸可视化检测探针构筑及细胞成像，横向课题

27.荞麦酒中风味物质及功能性成分的测定研究，横向课题

代表性学术论文：

1.Xianfeng Lin, Lixin Kang, Jiaqi Feng, Nuo Duan, Zhouping Wang, Shijia Wu^*. Versatile sensing strategies based on emerging programmable prokaryotic Argonautes: From nucleic acid to non-nucleic acid targets. Trends in Analytical Chemistry, 2025, 184, 118130.

2.Zhuowen Deng, Yong-Huan Yun, Nuo Duan, Shijia Wu^*.Artificial intelligence algorithms-assisted biosensors in the detection of foodborne pathogenic bacteria: Recent advances and future trends.Trends in Food Science & Technology, 2025, 161, 105072.

3.Zhiyuan Ning, Yingming Zhang, Shikun Zhang, Xianfeng Lin, Lixin Kang, Nuo Duan, Zhouping Wang, Shijia Wu^*. Cellular fluorescence imaging technology for food risk and function evaluation. Trends in Food Science & Technology, 2024, 153, 104742.

4.Shikun Zhang, Yingming Zhang, Zhiyuan Ning, Mengxia Duan, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu^*. Design and application of microfluidics in aptamer SELEX and Aptasensors. Biotechnology Advances, 2024, 77, 108461.

5.Jiajun Wu, Xianfeng Lin, Jin Li, Ziyu Lv, Nuo Duan, Zhouping Wang, ShijiaWu^*. Dual-color nanospheres based on aggregation-induced emission and catalytic hairpin assembly for simultaneous imaging of acrylamide and miR-21 in living cells. Journal of Hazardous Materials, 2024, 462, 132815.

6.Xianfeng Lin, Changxin Li, Xiangyi Meng, Wenyan Yu, Nuo Duan, Zhouping Wang, Shijia Wu^*. CRISPR-Cas12a-mediated luminescence resonance energy transfer aptasensing platform for deoxynivalenol using gold nanoparticle-decorated Ti₃C₂T_XMXene as the enhanced quencher. Journal of Hazardous Materials, 2022, 433, 128750.

7.Chuxian He, You Zhou, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu^*. Deoxynivalenol-induced cell apoptosis monitoring using a cytochrome c-specific fluorescent probe based on a photoinduced electron transfer reaction. Journal of Hazardous Materials, 2021, 415, 125638.

8.Jin Li, Xianfeng Lin, Jiajun Wu, Dichen Ying, Nuo Duan, Zhouping Wang, Shijia Wu^*. Multifunctional magnetic composite nanomaterial for Colorimetric-SERS Dual-Mode detection and photothermal sterilization of Vibrio parahaemolyticus. Chemical Engineering Journal, 2023, 477, 147113.

9.Lixin Kang, Jia Wang, Xianfeng Lin, Jiaqi Feng, Nuo Duan, Zhouping Wang, Shijia Wu^*. A Full-Color Carbon Quantum Dots Fluorescence Sensing Array Combined with Machine Learning for Rapid Bacterial Detection and Classification. Advanced Healthcare Materials, 2025, e02916.

10.Qinyan Xu, Xiaoyao Wang, Zepeng Gu, Nuo Duan, Sunming Jiang, Shijia Wu^*, Wenbo Yuan^*.An electrochemical/colorimetric sensor for 5-methyltetrahydrofolate based on a screened specific aptamer and DNA walker-driven CRISPR/Cas12a cascade amplification. Biosensors and Bioelectronics, 2025, 289, 117931.

11.Shikun Zhang, Zhiyuan Ning, Yingming Zhang, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu^*. Construction of a microfluidic SELEX platform for efficient screening of advanced glycation end products aptamer. Biosensors and Bioelectronics, 2025, 271, 117038.

12.Jiaqi Feng, Chunxia Lu, Xianfeng Lin, Lixin Kang, Nuo Duan, Zhouping Wang, Changbin Liu,Shijia Wu^*. A portable microfluidic chip-based fluorescent and colorimetric aptasensor combining recombinase polymerase amplification for bovine pregnancy-associated glycoproteins detection. Biosensors and Bioelectronics, 2025, 270, 116981.

13.Lixin Kang, Jiajun Wu, Xianfeng Lin, Jin Li, Nuo Duan, Zhouping Wang, Shijia Wu^*. Detection and simultaneous imaging of acrylamide, miR-21 and miR-221 based on multicolor aggregation-induced emission nanoparticles and DNAzyme walker. Biosensors and Bioelectronics, 2024, 264, 116628.

14.Nuo Duan, Yuting Chang, Tingting Su, Xinyue Zhang, Minghui Lu, Zhouping Wang, Shijia Wu^*. Generation of a specific aptamer for accurate detection of sarafloxacin based on fluorescent/colorimetric/SERS triple-readout sensor. Biosensors&Bioelectronics, 2024, 249, 116022.

15.Jiajia Lv, Sen Zhao,Shijia Wu^*, Zhouping Wang^*. Upconversion nanoparticles grafted molybdenum disulfide nanosheets platform for microcystin-LR sensing. Biosensors & Bioelectronics, 2017, 90, 203-209.

16.Shikun Zhang, Xianfeng Lin, Zepeng Gu, Lixin Kang, Yingming Zhang, Jun Sun, Nuo Duan, Zhouping Wang, Ruijie Deng, Shijia Wu^*. Machine learning assisted CRCA multi-color fluorescent droplet imaging for high-sensitivity simultaneous detection of Maillard hazards. iScience, 2025, 28, 9, 113212.

17.Xiaoyao Wang, Qinyan Xu, Zepeng Gu, Yingming Zhang, Shikun Zhang, Nuo Duan, Zhouping Wang, Shijia Wu^*. High-Affinity Aptamer Selection for Microbial Transglutaminase and Application in ColorimetricSERS Dual-Mode Detection. Analytical Chemistry, 2025,10.1021/acs.analchem.5c03609.

18.Lixin Kang, Xianfeng Lin, Jiaqi Feng, Mengxia Duan, Nuo Duan, Zhouping Wang, Shijia Wu^*. Machine Learning-Assisted Multiplexed Fluorescence-LabeledmiRNAs Imaging Decoding for Combined Mycotoxins ToxicityAssessment. Analytical Chemistry, 2025, 97, 14, 8001-8010.

19.Xianfeng Lin, Lixin Kang, Jiaqi Feng, Nuo Duan, Zhouping Wang, Shijia Wu^*. Deep Learning-Assisted Fluorescence Single-Particle Detection ofFumonisin B₁Powered by Entropy-Driven Catalysis and Argonaute. Analytical Chemistry, 2025, 97, 7, 4066-4074.

20.Wenyan Yu, Lixin Kang, Xianfeng Lin, Nuo Duan, Dichen Ying, Zhouping Wang, andShijia Wu^*. Deoxynivalenol (DON)-Triggered Dual-Color Composite Probe Based on Gold Nanoclusters for Simultaneous Imaging of DON and miR-34a in Living Cells. Analytical Chemistry, 2023, 95, 50, 18611-18618.

21.Shijia Wu, Nuo Duan, Shi Zhao, Congcong Fang, Zhouping Wang^*. Simultaneous Aptasensor for Multiplex Pathogenic Bacteria Detection Based on Multicolor Upconversion Nanoparticles Labels. Analytical Chemistry, 2014, 86,6, 3100-3107.

22.Zepeng Gu, Qinyan Xu, Xiaoyao Wang, Xianfeng Lin, Nuo Duan, Zhouping Wang,Shijia Wu^*. Food Freshness Prediction Platform Utilizing Deep Learning-BasedMultimodal Sensor Fusion of Volatile Organic Compounds andMoisture Distribution.ACS Sensors, 2025, 10, 4, 3091-3100.

23.Xinyu Tong, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu^*. Laser-Printed Paper-Based Microfluidic Chip Based on a Multicolor Fluorescence Carbon Dot Biosensor for Visual Determination of Multiantibiotics in Aquatic Products.ACS Sensors, 2022, 7, 12, 3947-3955.

24.Xianfeng Lin, Jin Li, Jiajun Wu, Kaixi Guo, Nuo Duan, Zhouping Wang, Shijia Wu^*. Fe-Co-Based Metal-Organic Frameworks as Peroxidase Mimics for Sensitive Colorimetric Detection and Efficient Degradation of Aflatoxin B₁. ACS Applied Materials & Interfaces, 2024, 16, 9, 11809-11820.

25.Xuhan Xia, Ting Zhang, Sha Deng, Junbo Chen,Shijia Wu^*, Chuxian He, Kaxixiang Zhang, Ruijie Deng*, Qiang He. Visualization of Mycotoxins in Living Cells Using Conformation-Resolved Aptamer Nanoprobes. ACS Sustainable Chemistry & Engineering, 2020, 8, 26, 9920-9925.

26.Jiaqi Feng, Jin Li, Xianfeng Lin, Lixin Kang, Nuo Duan, Zhouping Wang, Shijia Wu^*. A polydopamine coated magnetic spiral switchable composite material for photothermal sterilization and dual-color fluorescence detection of food-borne pathogens. Sensors and Actuators: B. Chemical, 2025, 425, 136935.

27.Xianfeng Lin, Kaixi Guo, Zhongxiang Wang, Lixin Kang, Nuo Duan, Zhouping Wang, Shijia Wu^*. Construction of aptamer-gated colorimetric sensor based on MIL-acetylcholinesterase to detect acrylamide in food. Sensors and Actuators B: Chemical, 2024, 418, 136338.

28.Xinyu Tong, Xianfeng Lin, Nuo Duan, Ziyu Lv, Zhouping Wang,Shijia Wu^*. A novel colorimetric and fluorescent dual-mode 3D paper-based microfluidic aptasensor for the point-of-care detection of sulfadimethoxine. Sensors and Actuators: B. Chemical, 2023, 397, 134691.

29.Shijia Wu, Nuo Duan, Xiaoyuan Ma, Yu Xia, Ye Yu, Zhouping Wang^*, Hongxin Wang. Simultaneous detection of enterovirus 71 and coxsackievirus A16 using dual-colour upconversion luminescent nanoparticles as lables. Chemical Communications, 2012, 48, 40, 4866-4868.

30.Yingming Zhang, Shikun Zhang, Zhiyuan Ning, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu. Development of an Automated Capture-SELEX Device for EfficientScreening ofβ‑Conglycinin Aptamer. Journal of Agricultural and Food Chemistry, 2024, 72, 50, 28148-28156.

31.Nuo Duan, Kexin Ren, Chen Lyu, Zhouping Wang, Shijia Wu^*. Discovery and Optimization of an Aptamer and Its Sensing Ability to Amantadine Based on SERS via Binary Metal Nanoparticles. Journal of Agricultural and Food Chemistry, 2022, 70, 46, 14805-14815.

32.Lehan Zhao, Xianfeng Lin, Nuo Duan, Imran Mahmood Khan, Zhouping Wang, Shijia Wu^*. A sensitive fluorescent assay based on gold-nanoclusters coated on molecularly imprinted covalent organic frameworks and its application in malachite green detection. Food Chemistry, 2023, 410, 135425.

33.Xianfeng Lin, Changxin Li, Xinyu Tong, Nuo Duan, Zhouping Wang, Shijia Wu^*. A portable paper-based aptasensor for simultaneous visual detection of two mycotoxins in corn flour using dual-color upconversion nanoparticles and Cu-TCPP nanosheets. Food Chemistry, 2023, 404, 134750.

1.中国粮油学会第三届青年科技奖，2022，排名第一

2.“食品安全危害物适配体SELEX筛选体系及纳米生物界面组装研究”，高等学校科学研究优秀成果奖-自然科学奖二等奖，2017，排名第二

3.“食品安全纳米生物检测技术研究及产业化示范”，中国轻工业联合会科技进步奖二等奖，2014，排名第二

4.“食源性致病菌/真菌毒素纳米生物传感检测技术研究及应用”，中国食品科学技术学会科技进步奖三等奖，2014，排名第二

5.“食品中真菌毒素检测新技术研究”，中山市科学技术进步奖二等奖，2014，排名第四

已授权发明专利：

1.一种基于多色碳量子点的纸基微流控检测抗生素的方法，授权，2025年8月26日，发明人：吴世嘉，佟鑫玉，段诺，林先锋，专利号：ZL202211432825.1

2.一种比色-荧光双模式三维纸基微流控芯片及其制备和应用，授权，2025年8月1日，发明人：吴世嘉，佟鑫玉，段诺，林先锋，吕紫钰，专利号：ZL202310585758.5

3.一种测定己烯雌酚的适配体-分子印迹荧光共价有机框架传感器及其制备和应用，授权，2025年6月3日，发明人：吴世嘉，赵乐涵，段诺，林先锋，郭恺曦，专利号：ZL202310612539.1

4.一种光动力/光热协同抗菌型MOF基包装薄膜的制备方法及其应用，授权，2025年3月25日，发明人：吴世嘉，闫晗，段诺，郭恺曦，专利号：ZL202310354473.0

5.一种MOF基食品包装膜及其制备方法，授权，2024年10月11日，发明人：吴世嘉，闫晗，段诺，张世坤，张英明，宁致远，专利号：ZL202310775860.1

6.一种基于DON控制的双色复合探针对DON和miR-34a同时细胞成像的方法，授权，2024年4月30日，发明人：吴世嘉，余文艳，段诺，林先锋，专利号：ZL202310604704.9

7.一种可视化监测活细胞中细胞色素C和评估呕吐毒素细胞毒性的方法，授权，2021年12月28日，发明人：吴世嘉，何楚娴，周游，林先锋，专利号：ZL202110149119.5

8.一种用于赭曲霉毒素A快速检测的上转换适配体试纸条的制备方法，授权，2021年5月11日，发明人：吴世嘉，刘丽红，段诺，王周平，虞倩茹，专利号：ZL201810502981.8

9.一种复合纳米材料光催化降解脱氧雪腐镰刀菌烯醇的方法，授权，2020年8月18日，发明人：吴世嘉，王芳，王周平，段诺，李倩，周游，专利号：ZL201810377179.0

10.一种适配体过氧化物模拟酶可视化检测沙门氏菌的方法，授权，2019年7月30日，发明人：吴世嘉，段诺，王周平，刘丽红，专利号：ZL201710253103.2

11.一种基于上转换发光纳米材料和金纳米棒之间发光共振能量转移检测赭曲霉毒素A的方法，授权，2018年9月11日，发明人：吴世嘉，戴邵亮，王周平，段诺，专利号：ZL201510633405.3

12.一种基于荧光共振能量转移检测伏马菌毒素B1的方法，授权，2016年9月28日，发明人：王周平，吴世嘉，段诺，马小媛，夏雨，专利号：ZL201210570159.8

13.一种基于多色上转换荧光标记同时检测三种食源性致病菌的方法，授权，2016年6月22日，发明人：王周平，吴世嘉，段诺，史召，方聪聪，专利号：ZL201410057135.1

14.试纸条荧光生物检测系统，授权，2016年4月13日，发明人：王周平，吴世嘉，戴邵亮，段诺，李琪，夏雨，马小媛，专利号：ZL201520946179.X

15.超高压液相色谱—飞行时间质谱同时测定白酒中六种微量甜味剂的方法，授权，2012年6月27日，发明人：王洪新，吴世嘉，陶冠军，专利号：ZL200910184787.0

16.一种适配体功能化磁性纳米材料磁分离—上转换荧光纳米材料标记检测赭曲霉毒素A的方法，授权，2012年2月22日，发明人：王周平，吴世嘉，段诺，专利号：ZL201010295782.8

《食品安全学》本科生

《食品质量与安全》本科生

《微生物与食品安全》研究生

《食品安全风险与评估》研究生