[1]“抗炎免疫药理学”，国家自然科学基金优秀青年科学基金；主持，2022-2024，项目号82122068

[2]“肠道菌群-SCFAs-巨噬细胞轴在慢性胰腺炎中的作用及机制研究”，国自然科学基金面上项目，2021-2024，主持，项目号82070666

[3]“丁酸及产丁酸菌在维持肠道稳态及重症胰腺炎中的作用研究”，国自然科学基金面上项目，主持，2019.01-2022.12，项目号81870439

[4]“肠道丁酸在1型糖尿病免疫炎症中作用及分子机制研究”，国家自然科学基金面上项目，主持，2016.01-2019.12，项目号31570915

[5]“抗菌肽cathelicidins在维持肠道免疫稳态及1型糖尿病发病中的作用研究”，国家自然科学基金重大研究计划（培育项目），主持，2017.01-2019.12，项目号91642114

[6]“自身免疫型糖尿病中肠源抗菌肽的功能研究“，江苏省自然科学基金杰出青年项目，2020-2022，项目号BK20200026

[7]“针对胰腺健康的酪酸梭菌研究开发”，江苏省双创计划团队项目，2019.01-2021.12

[8]“糖尿病前期代谢功能障碍危险因素识别与精准干预策略研究“；“四大慢病”国际科技重大专项；子课题，2025-2029

[9]“2025年度I型糖尿病防控关键技术研发"；”中国1型糖尿病多组学动态预警与慧化精准防控体系技术研发“，江苏省科技计划项目，课题，2025-2027

[10]“短链脂肪酸调控胰肠区域免疫稳态及机理研究”,中央高校专项自主科研项目-重点项目（A类），主持，项目号JUSRP51613A ，2016.01-2018.12

[11]“功能脂肪酸与抗菌肽的健康机理与药食应用研究”,国家海外高层次人才项目，主持，2015.01-2017.12

[12]“抗菌肽的天然诱导剂筛选”，国家高端外国专家项目，中方负责人，2014.01-2015.12

[13]“抗菌肽cathelicidins 对beta 细胞功能的免疫调节作用及机理研究”，国家自然科学基金青年项目，主持，2015.01-2017.12

[14]“功能活性物质的内源诱导对宿主免疫防御与慢性病防治的影响及相关新型营养产品的开发”，江苏省双创计划人才项目，主持，2015.01-2017.12

[15]“新型抗糖尿病胰岛炎症的免疫防御肽内源诱导剂的开发”，江苏省六大人才高峰项目，主持，2015.91-2017.12

[16]“膳食脂肪与宿主防御肽在胰腺beta细胞功能和糖尿病预防重的作用与机制研究”，江苏省自然科学基金青年项目，主持，2014.01-2016.12

[1]Sun J, Laetitia Furio, Ramine Mecheri, Anne M. van der Does, Erik Lundeberg, Loredana Saveanu, Yong Chen, Peter van Endert, Birgitta Agerberth, Julien Diana. Pancreatic β-cells express a host defense peptide regulating autoimmune diabetes under the influence of the gut microbiota. Immunity. 2015; 43: 304-317. (IF: 24.1,封面文章)

[2]LiangWJ; EnéeE; Andre-ValleeC; FalconeM; Sun J*; Diana J,; Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota Against Pancreatic Autoimmunity, Gastroenterology, 2022, 162(4): 1288-1302.e16.（IF：25.1）

[3]Ren Z, Pan LL, Huang Y, Chen H, Liu Y, Liu H, Tu X, Liu Y, Li B, Dong X, Pan X, Li H, Fu YV, Agerberth B, Diana J, Sun J*. Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy. EMBO Mol Med. 2021 Jun 14. doi: 10.15252/emmm.202114059. (IF: 12.13,封面文章)

[4]Pan LL, Ren Z, Li B, LiangWJ, LuoY, YangQ, LiuH, Dong XL, TianHZ, ZouHM, SamuelssonB, RådmarkO, SunJ*; Coactosin-Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation, Advanced Sicence, 2025, Sep; 12(34): e01673.（IF：14.1）

[5]Pan LL; Ren Z; YangJ; Li B; HuangYW; SongDX; LiX; XuJJ; BhatiaM; ZouDW; Zhou CH; Sun J*; Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram positive bacteria, Acta Pharmaceutica Sinica B, 2023, 13(10): 4202-4216.（IF：14.6, 唯一通讯，封面文章）

[6]Pan X, Zhu Q, Pan LL, Sun J*. Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy. Pharmacol Ther. 2022 Oct;238:108176. doi: 10.1016/j.pharmthera.2022.108176. Epub 2022 Mar 26. PMID: 35346728. （IF：12.5）

[7]Pan LL, Ren Z, Tu X, Liu H, Tay HL, Li J, Pan X, Dong X, Foster PS, Sun J*. GPR109A deficiency promotes IL-33 overproduction and type 2 immune response in food allergy in mice. Allergy. 2021 Apr 8. doi: 10.1111/all.14849. (IF: 13.14)

[8]Pan LL; SunYD; DongXL; RenZN; Li,BB; YangP; ZhangL; Sun J*; Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production, Gut Microbes, 2024, 16(1): 2430541.（IF：11.0）

[9]Jia L, Li J, Zhang M, Liu H, Ren Z, Dong XL, Pan X, Qiu J, Pan LL, Sun J*. Cathelicidin-related antimicrobial peptide protects against enteric pathogen-accelerated type 1 diabetes in mice. Theranostics. 2022 Apr 24;12(7):3438-3455. (IF: 12.4)

[10]Li J, Pan X, Ren Z, Li B, Liu H, Wu C, Dong X, de Vos P, Pan LL, Sun J*. PRMT2 promotes dextran sulfate sodium-induced colitis by inhibiting SOCS3 via histone H3R8 asymmetric dimethylation. Br J Pharmacol. 2021 Jul. Accepted. (IF: 8.739)

[11]Li JH, Zhang M, Zhang ZD, Pan XH, Pan LL, Sun J*. GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation. Acta Pharmacol Sin. 2024 Jul;45(7):1466-1476. （IF：8.2）

[12]Li B, Pan LL, Pan X, Dong X, Ren Z, Zhang H, Chen W, de Vos P, Sun J*. Opportunities and challenges of polyphenols and polysaccharides for type 1 diabetes intervention. Crit Rev Food Sci Nutr. 2024;64(10):2811-2823. （IF：8.8）

[13]Dong X, Qu L, Xiong J, Wang B, Sha X, Wu B, Sun Y, Pan X, Sun J*, Pan LL. Shizukaol C alleviates trimethylamine oxide-induced inflammation through activating Keap1-Nrf2-GSTpi pathway in vascular smooth muscle cell. Phytomedicine. 2024 Jun;128:155403.（IF：8.0）

[14]Liu H, Dong X, Jia K, Yuan B, Ren Z, Pan X, Wu J, Li J, Zhou J, Wang RX, Qu L, Sun J*, Pan LL. Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation. Cardiovasc Res. 2023 Sep 5;119(11):2142-2156.(IF：13.3）

[15]Dong XL, Yuan BH, Yu SZ, Liu H, Pan XH, Sun J*, Pan LL. Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation. Acta Pharmacol Sin. 2023 Mar;44(3):573-583. （IF：8.2）

[16]Yang Y, Huang C, Hui L, Song Y, Fu Y, Li M, Yang H, Wu J, Sun J*, Xu W, Wei L. Cathelicidins Target HSP60 To Restrict CVB3 Transmission via Disrupting the Exosome and Reducing Cardiomyocyte Apoptosis. J Virol. 2023 Mar 30;97(3):e0143322. （IF：4.0）

[17]Jia LL, Zhang M, Liu H, Sun J*, Pan LL. Early-life fingolimod treatment improves intestinal homeostasis and pancreatic immune tolerance in non-obese diabetic mice. Acta Pharmacol Sin. 2021 Jan 20. doi: 10.1038/s41401-020-00590-4. (IF: 6.15)

[18]Pan LL, Li BB, Pan XH, Sun J*. Gut microbiota in pancreatic diseases: possible new therapeutic strategies. Acta Pharmacol Sin. 2021 Jul;42(7):1027-1039. doi: 10.1038/s41401-020-00532-0.(IF: 6.15,封面文章)

[19]Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X, Sun J*, Yang J, Pan LL. Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer. Biochem Pharmacol. 2020 Dec;182:114289. doi: 10.1016/j.bcp.2020.114289. (IF: 5.852)

[20]Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J, Sun J*. A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation. J Cell Mol Med. 2020 Nov;24(22):12955-12969. doi: 10.1111/jcmm.15890. (IF: 5.313)

[21]Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J*, Pan LL. Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway. Antioxidants (Basel). 2020 Jun 5;9(6):491. doi: 10.3390/antiox9060491. (IF: 6.312)

[22]Pan LL, Liang W, Ren Z, Li C, Chen Y, Niu W, Fang X, Liu Y, Zhang M, Diana J, Agerberth B, Sun J*. Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice. Br J Pharmacol.2020 Jan 24. doi: 10.1111/bph.14998. (IF: 7.7)

[23]Zhou Q, Pan LL, Xue R, Ni G, Duan Y, Bai Y, Shi C, Ren Z, Wu C, Li G, Agerberth B, Sluijter JP, SunJ*, Xiao J. The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure. Theranostics.2020 15;10(14):6167-6181. doi: 10.7150/thno.46225. (IF: 8.6)

[24]Pan X, Fang X, Wang F, Li H, Niu W, Liang W, Wu C, Li J, Tu X, Pan LL, Sun J*. Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue specific mechanisms. Br J Pharmacol.2019 Jul 26. doi: 10.1111/bph.14806.(IF: 7.7)

[25]Bei Y#, Pan LL#, Zhou Q#, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J*, Xiao J*. Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury. BMC Med. 2019. DOI: 10.1186/s12916-019-1268-y. (IF: 9.1)

[26]Pan X, Li J, Tu X, Wu C, Liu H, Luo Y, Dong X, Li X, Pan LL, Sun J*. Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-β1/Smad3 pathway. Pharmacol Res.2020 152:104592. doi: 10.1016/j.phrs.2019.104592. (IF: 5.6)

[27]Li J, Pan X, Yang J, Jia L, Wu C, He L, Ren Z, Pan L, Sun J*. Enteral virus depletion modulates experimental acute pancreatitis via toll-like receptor 9 signaling. Biochem Pharmacol.2020;171:113710. (IF: 4.96)

[28]Jia L, Cao M, Chen H, Zhang M, Dong X, Ren Z, Sun J*, Pan LL*. Butyrate Ameliorates Antibiotic-Driven Type 1 Diabetes in the Female Offspring of Nonobese Diabetic Mice. J Agric Food Chem.2020 Mar 11;68(10):3112-3120. doi: 10.1021/acs.jafc.9b07701. (IF: 4.2)

[29]Jia L, Chen H, Yang J, Fang X, Niu W, Zhang M, Li J, Pan X, Ren Z, Sun J*, Pan LL. Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway. Innate Immun. 2020 Jan;26(1):48-61. doi: 10.1177/1753425919881502. (IF: 2.648)

[30]Liu H, Pan LL, Lv S, Yang Q, Zhang H, Chen W, Lv Z, Sun J*. Alterations of Gut Microbiota and Blood Lipidome in Gestational Diabetes Mellitus With Hyperlipidemia. Front Physiol. 2019 Aug 6. doi: 10.3389/fphys.2019.01015. (IF: 4.562)

[31]Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J*. Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction. Mol Nutr Food Res. 2019 Aug 18:e1900307. doi: 10.1002/mnfr.201900307. (IF: 5.3)

[32]Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J*. Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice. Front Immunol. 2019 Jul 30;10:1733. doi: 10.3389/fimmu.2019.01733. eCollection 2019. (IF: 5.0)

[33]Pan LL, Niu W, Fang X, Liang W, Li H, Chen W, Zhang H, Bhatia M, Sun J*. Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis. Mol Nutr Food Res. 2019 Apr 29:e1801419. doi: 10.1002/mnfr.201801419. (IF: 5.3)

[34]Sun J*, de Vos P. Editorial: Immunomodulatory Functions of Nutritional Ingredients in Health and Disease. Front Immunol. 2019 Jan 24;10:50. doi: 10.3389/fimmu.2019.00050. eCollection 2019. (IF: 5.0)

[35]Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL, Sun J*. A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis. Front Immunol. 2018; 9:2513. (IF: 5.0)

[36]Pan LL, Deng Y-Y, Wang R, Wu C, Li J, Niu W, Yang Q, Madhav B, Gudmundsson HG, Agerberth B, Diana J and Sun J*. Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice. Front Immunol. 2018; 9:751. (IF: 5.0)

[37]He Y, Wu C, Li J, Li H, Sun Z, Zhang H, de Vos P, Pan LL*, Sun J*. Inulin-Type Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. Front Immunol. 2017; 8:1209. (IF: 5.0)

[38]Jia L, Shan K, Pan LL, Feng N, Lv Z, Sun Y, Li J, Wu C, Zhang H, Chen W, Diana J, Sun J*, Chen YQ*. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017; 8:1345. (IF: 5.0)

[39]Pan LL, Li J, Shamoon M, Bhatia M, Sun J*. Recent Advances on Nutrition in Treatment of Acute Pancreatitis. Front Immunol. 2017; 8:762. (IF: 5.5)

[40]Sun J*, Xu M, Diana J, Ortsäter H,‎Flodström-Tullberg M, Haeggström Z. J, Agerberth B. The antimicrobial peptide cathelicidin is a positive regulator of pancreaticβ-cell function. FASEB J. 2016;30: 884-894. (IF: 5.6)

[41]Muhammad Shamoon, Yongquan Chen, Madhav Bhatia*, Sun J*. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016; 20: 73-87. (IF: 4.9)

[42]Chen K, Chen H, M Faas M, J de haan B, Li J, Xiao P, Zhang H, Diana J, de Vos P, Sun J*. Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function and microbiota homeostasis. Mol Nutr Food Res 2017; 61(8)(IF: 5.2)

[43]Sun Y, He Y, Wang F, Zhang H, de Vos P, Sun J*. Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis. Mol Nutr Food Res 2017; 61(4) (IF: 5.2)

[44]Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J*. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxid Med Cell Longev 2016; 2016:7864150. (IF: 4.9)

[45]Sun J, Dahlén B, Agerberth B, Haeggström ZJ. The host defense peptide LL-37 induces release of eicosanoids and eosinophil cationic protein from human eosinophils – implications for asthma. Allergy. 2013;68:304-311. (IF:6.0)

[46]Sun J, Ramnath RD, Tamizhselvi R, Bhatia M. PKC and PI3K-Akt Pathways are Involved in Substance P-Induced ERK1/2-NF-κB Activation and Chemokine Expression in Mouse Macrophages. FASEB J. 2009;23:997-1010. (IF:6.401)

[47]Sun J, Ramnath RD, Zhi L, Tamizhselvi R, Bhatia M. Substance P Enhances NF-κB Transactivation and Chemokine Response in Murine Macrophages via ERK1/2 and p38 MAPK Signaling Pathways. Am J Physiol Cell Physiol. 2008; 294:C1586-1596. (IF:4.230)

获美国（1项）和中国发明专利授权13项、转让1项。

本科生课程

食品新生导论

微生物学 （实验）

研究生课程

分子细胞生物学

营养免疫与健康

食品营养与代谢

指导博士生12人，毕业5人，其中江南大学优秀毕业生2人

指导硕士生21人，毕业17人，获得江苏研究生实践创新计划8项