李言，理学博士，博士毕业于中国科学院上海营养与健康研究所，目前任职于江南大学食品学院，研究员，博士生导师。兼任中国生物物理学会代谢生物学分会理事、中国生物物理学会运动与健康分会理事、中国粮油学会食品分会理事、《食品科学技术学报》编委等工作。围绕食品基础营养物质和功能活性成分的结构组成特点开展营养相关应用基础研究，在精准营养评估、分子机理研究与产业化应用方面形成了特色研究。申请人主持科技部重点研发计划子课题2项，国家自然科学基金面上项目、青年基金项目各1项，入选中国科协“青年人才托举工程”等人才项目；以第一/通讯作者在PNAS、Cell Chem Biol、Compr Rev Food Sci F、Aging Cell、J Agric Food Chem等重要期刊发表论文60余篇，其中SCI论文53篇；研究工作应用于国内外多家知名运动营养与健康食品企业，取得较好的社会经济效益，获2022年中国商业联合会科技进步特等奖；以第一发明人申请国家发明专利8项，授权3项。
1.国家自然科学基金委，面上项目，32071166，mTOR乳酸化修饰在骨骼肌自噬调控中的作用及机制研究，2021-01至2024-12，58万元，在研，主持
2.国家自然科学基金委，青年科学基金项目，31900841，miR-183/96在骨骼肌减少症中的作用及机制研究，2020-01至2022-12，25万元，在研，主持
3.中国科学技术协会，青年人才托举工程项目，2020QNRC001，谷物营养与代谢调控，2021-02至2023-01，45万元，在研，主持
1. Liu, J., C. Nie, L. Xue, Y. Yan, S. Liu, J. Sun, M. Fan, H. Qian, H. Ying, L. Wang＃, andY. Li＃, Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.Theranostics, 2021. 11(17): p. 8283-8300.
2. Wang, H., M. Ma, Y. Li, J. Liu, C. Sun, S. Liu, Y. Ma, Y. Yan, Z. Tang, S. Shen, J. Yu, Y. Wu, J. Jiang, L. Wang, Z.B. Jin, H. Ying＃, andY. Li＃, miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle.EMBO Rep, 2021. 22(9): p. e52247.
3. Y. Li, J. Jiang, W. Liu, H. Wang, L. Zhao, S. Liu, P. Li, S. Zhang, C. Sun, Y. Wu, S. Yu, X. Li, H. Zhang, H. Qian, D. Zhang, F. Guo, Q. Zhai, Q. Ding, L. Wang, and H. Ying, microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle.Proc Natl Acad Sci USA, 2018. 115(46): p. E10849-E10858.
4. Zhang, K.L., J. Sun, M.C. Fan, H.F. Qian, H. Ying,Y. Li＃, and L. Wang＃, Functional ingredients present in whole-grain foods as therapeutic tools to counteract obesity: Effects on brown and white adipose tissues.Trends in Food Science & Technology, 2021. 109: p. 513-526.
5. Liu, J.X., Y. Wang, L.M. Xue, C. Nie, J. Sun, M.C. Fan, H.F. Qian, L. Wang＃, andY. Li＃, Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.Journal of Agricultural and Food Chemistry, 2021. 69(30): p. 8440-8447.
6. Yang, Z., J.Y. Mi, Y. Wang, L.M. Xue, J.X. Liu, M.C. Fan, D. Zhang, L. Wang, H.F. Qian, andY. Li＃, Effects of low-carbohydrate diet and ketogenic diet on glucose and lipid metabolism in type 2 diabetic mice.Nutrition, 2021. 89.
7. Wang, Y.C., X.H. Yao, M. Ma, H.H. Zhang, H. Wang, L. Zhao, S.N. Liu, C. Sun, P. Li, Y.T. Wu, X.H. Li, J.J. Jiang, Y.Y. Li,Y. Li＃, and H. Ying＃, miR-130b inhibits proliferation and promotes differentiation in myocytes via targeting Sp1.Journal of Molecular Cell Biology, 2021. 13(6): p. 422-432.
8. Liu, J.X.*,Y. Li*＃, C. Sun, S.N. Liu, Y. Yan, H.O. Pan, M.C. Fan, L.M. Xue, C.Z.P. Nie, H. Zhang, H.F. Qian, H. Ying, and L. Wang＃, Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.Pharmacological Research, 2020. 152.
9. Liu, J.X.,Y. Li＃, L.M. Xue, M.C. Fan, C.P. Nie, Y. Wang, H. Zhang, H.F. Qian, and L. Wang＃, Circulating miR-27a-3p as a candidate for a biomarker of whole grain diets for lipid metabolism.Food & Function, 2020. 11(10): p. 8852-8865.
10. Nie, C.Z.P.*,Y. Li*＃, H.F. Qian, H. Ying, and L. Wang＃, Advanced glycation end products in food and their effects on intestinal tract.Critical Reviews in Food Science and Nutrition, 2020.p. 1-13.
11.Y. Li＃, H.O. Pan, J.X. Liu, T.T. Li, S.N. Liu, W.L. Shi, C. Sun, M.C. Fan, L.M. Xue, Y. Wang, C.Z.P. Nie, H. Zhang, H.F. Qian, H. Ying, and L. Wang, L-Arabinose Inhibits Colitis by Modulating Gut Microbiota in Mice.Journal of Agricultural and Food Chemistry, 2019. 67(48): p. 13299-13306.
12.Y. Li, H.O. Pan, X.T. Zhang, H. Wang, S.N. Liu, H. Zhang, H.F. Qian, L. Wang, and H. Ying, Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle.Journal of Agricultural and Food Chemistry, 2019. 67(16): p. 4483-4492.
