1.国家自然科学基金面上项目，适配体介导的DNA水凝胶对志贺毒素毒性抑制作用及机理研究（32272449），主持

2.国家自然科学基金面上项目，适配体定向掩盖β-乳球蛋白致敏位点的脱敏行为及机理研究（31871721），主持

3.国家自然科学基金青年项目，适配体识别-分子马达传感器的构建及在食源性致病菌检测中的应用研究（31401575），主持

4.十四五国家重点研发计划青年科学家项目子课题，畜禽肉有害微生物智能化传感检测技术研究（2025YFD2100500），主持

5.十四五国家重点研发计划子课题，食品风险综合评价技术研究（2022YFF110110306），主持

6.十三五国家重点研发计划子课题，核酸适配体资源库构建与筛选技术研究（2018YFC1602900），主持

7.十三五国家重点研发计划子课题，食品品质质量多维交互识别与检测技术（2016YFD0401204），主持

8.江苏省自然科学基金，基于适配体识别的表面增强拉曼光谱检测食源性致病菌的研究（BK20140155），主持

9.江苏省农业科技自主创新资金，基于功能核酸多模态传感检测农产品中危害物的关键技术研究（CX（22）3006），主持

10.中国博士后科学基金-特别资助，适配体界面组装技术研究及在重金属脱除中的应用（2018T110443），主持

11.中国博士后科学基金-面上资助，基于适配体识别-可视化信号放大传感检测重金属的研究（2017M610299），主持

12.江苏省博士后科研资助计划，呕吐毒素适配体非固定化筛选技术与应用研究（1701097B），主持

13.乳业生物技术国家重点实验室开放基金，乳制品中β-乳球蛋白新型识别与传感检测技术研究（SKLDB2020-002），主持

14.江苏省市场监管重点实验室开放课题，基于微流控多模态免疫传感的牛羊肉真实性快速鉴别技术及装备研究（KFZ202503），主持

15.江南大学至善青年学者支持计划，食品危害物多模态传感检测方法构建（JUSRP622025），主持

16.基于磁性纳米微球-ATP生物发光快速检测食源性致病菌的方法研究，横向课题

17.大米新鲜度快速测定技术，横向课题

18.牛乳中污染物快速检测技术研究，横向课题

19.食品危害物毒性精准筛查及联合效应评估，横向课题

20.微生物富集技术及自动化设备研发，横向课题

1.Mengxia Duan, Man Ding, Kuaile Wu, Zhouping Wang, Shijia Wu, Nuo Duan*. Spatially confined multivalent aptamers in the cavity of a DNA nanocage against bacterial superantigens infection. Nano Today, 2026, 66, 102899.

2. Kuaile Wu, Mengxia Duan, Yalin Mo, Man Ding, Ning Ma, Zhouping Wang, Shijia Wu, Nuo Duan*. Signal hijacking and ROS attack antibacterial strategy using QS-interfering aptamer and bimetallic MOF. Chemical Engineering Journal. 2026, 543, 178291.

3.Man Ding, Mengxia Duan, Shiping Luo, Meihua Dong, Zhuowen Deng, Kuaile Wu, Ning Ma, Shijia Wu, Nuo Duan*. In situ monitoring of ferroptosis via dual-mode imaging of TFR1 expression using an aptamer-engineered MOF-Ag nanohybrid. Biosensors and Bioelectronics. 2026, 308, 118794.

4.Yuting Chang, Tingting Su, Mengxia Duan, Man Ding, Kuaile Wu, Zhouping Wang, Shijia Wu, Nuo Duan*. Rational engineering of a polyvalent aptamer for mitigating Aflatoxin B1 toxicity by disrupting metabolite Aflatoxin B1-8, 9-epoxide formation. Journal of Hazardous Materials. 2026, 501, 140701.

5.Mengxia Duan, Minghui Lu, Man DingZhouping Wang, Shijia Wu, Nuo Duan*. PdIr bimetallic nanozyme engineered metal-organic frameworks integrated dual-mode sensor toward Stx2 detection in food. Food Chemistry. 2026, 525, 150347.

6.Mengxia Duan, Wenxiu Zheng, Zepeng Gu, Man Ding, Shiping Luo, Zhouping Wang, Shijia Wu, Yukun Huang*, Nuo Duan*. Artificial neural network data fusion-mediated dual-mode sensor based on Fe3O4@PdIr for Salmonella typhimurium detection in food. Food Research International. 2026, 242, 119957.

7.Man Ding, Hong Xu, Mengxia Duan, Meihua Dong, Kuaile Wu, Shijia Wu, Changqing Zhu, Nuo Duan*. Electrochemical aptasensor for trimethoprim detection based on Pd@Ir bimetallic nanoparticles coupled with hybrid chain reaction. Sensors & Actuators B: Chemical. 2026, 454, 139575

8.Mengxia Duan, Yuting Chang, Kuaile Wu, Lixin Kang, Jiaqi Feng, Zhouping Wang, Shijia Wu, Nuo Duan*. Spatially and Multivalent Matched Neutralizing Aptamer-Based DNA Nanostructure Alleviates Shiga Toxin Type 2 Infection. Analytical Chemistry, 2025,97, 25346-25355.

9.Tingting Su, Yingming Zhang, Yuting Chang, Xianfeng Lin, Meihua Dong, Shijia Wu, Zhouping Wang, Nuo Duan*. Nanozyme meets pathogen: A M-MXene@CuS platform for triple-mode detection and synergistic inactivation of MRSA. Chemical Engineering Journal. 2025, 519, 165639.

10.Yalin Mo, Kuaile Wu, Ye Zheng, Ning Ma, Zhouping Wang, Shijia Wu, Nuo Duan*. In silico-guided engineering of broad-spectrum aptamer for the highly sensitive detection of organophosphate pesticides. Chemical Engineering Journal. 2025, 517, 164540.

11.Man Ding, Mengxia Duan, Shijia Wu, Nuo Duan*. Unraveling the mysteries of food allergens: aptamer-driven detection and suppression strategies. Food Research International. 2025, 219, 117021.

12.Kuaile Wu, Yalin Mo, Mengxia Duan, Yan Zheng, Yuting Chang, Man Ding, Zhouping Wang, Shijia Wu, Nuo Duan*. A Structure-Guided Bifunctional Aptamer Mitigates Pseudomonas aeruginosa Virulence and Biofilms by Disrupting las and rhl Quorum Sensing Systems. Analytical Chemistry, 2025, 97, 20291-20302.

13.Mengxia Duan, Yuting Chang, Xiaowan Chen, Zhouping Wang, Shijia Wu, Nuo Duan*. Recent advances in the construction strategy, functional properties, and biosensing application of self-assembled triangular unit-based DNA nanostructures. Biotechnology Advances. 2024, 70, 108436.

14.Tingting Su, Yuting Chang, Minghui Lu, Xianfeng Lin, Zhiyuan Ning, Shijia Wu, Zhouping Wang, Nuo Duan*. Bimetallic loaded ZIF-8 with peroxidase-like and photothermal activities for sensitive detection and efficient elimination of Listeria monocytogenes. Chemical Engineering Journal. 2024, 497, 154918.

15.Nuo Duan, Yuting Chang, Tingting Su, Xinyue Zhang, Minghui Lu, Zhouping Wang, Shijia Wu*. Generation of a specific aptamer for accurate detection of sarafloxacin based on fluorescent/colorimetric/SERS triple-readout sensor. Biosensors and Bioelectronics. 2024, 249, 116022.

16.Xiaowan Chen, Mengxia Duan, Yuting Chang, Mingyue Ye, Zhouping Wang, Shijia Wu, Nuo Duan*. Assembly of a multivalent aptamer for efficient inhibition of thermostable direct hemolysin toxicity induced by Vibrio parahaemolyticus. Journal of Hazardous Materials. 2024, 478, 135452.

17.Mingyue Ye, Xianfeng Lin, Jin Li, Xiaowan Chen, Dichen Ying, Shijia Wu, Zhouping Wang, Nuo Duan*. Dual-mode aptasensor based on P-CeO2NR@Mxene and exonuclease I-assisted target recycling for malachite green detection. Food Chemistry. 2024, 451, 139399.

18.Mingyue Ye, Tingting Su, Jin Li, Xiaowan Chen, Dichen Ying, Shijia Wu, Zhouping Wang, Nuo Duan*. Multifunctional Ce-MOF@PdNPs with colorimetric fluorescent electrochemical activity for ultrasensitive and accurate detection of diethylstilbestrol. Nano Research. 2024, 17, 9990-9998.

19.Mengxia Duan, Kexin Ren, Xiaowan Chen, Yuting Chang, Ziyu Lv, Zhouping Wang, Shijia Wu, Nuo Duan*. Discovery and design of an aptamer that inhibits Shiga toxin type 2 activity by blocking Stx2 B subunit-Gb3 interaction. International Journal of Biological Macromolecules, 2024, 277, 134365.

20.Xiaowan Chen, Yuting Chang, Mingyue Ye, Zhouping Wang, Shijia Wu, Nuo Duan*. Rational Design of a Robust G‑Quadruplex Aptamer as an Inhibitor to Alleviate Listeria monocytogenes Infection. ACS Applied Materials & Interfaces. 2024, 16, 15946-15958.

21. Yuting Chang, Wenxiu Zheng, Mengxia Duan, Tingting Su, Zhouping Wang, Shijia Wu, Nuo Duan*. Construction of Aptamer-Functionalized DNA Hydrogels for Effective Inhibition of Shiga Toxin II Toxicity. Journal of Agricultural and Food Chemistry. 2024, 72, 23533-23543.

22. Shuo Qi, Xiaoze Dong, Sobia Niazi, Minghui Lu, Nuo Duan*, Zhouping Wang*. Structure-guided engineering of aptamers to enhanced structural stability and application performance in alleviating β-lactoglobulin allergenicity. Chemical Engineering Journal. 2023, 473, 145450.

23.Nuo Duan, Mingyue Ye, Minghui Lu, Xiaowan Chen, Shijia Wu*. DNA aptamers selection and characterization for development of impedimetric aptasensor for Bacillus cereus at different growing stages. Advanced Agrochem, 2023, 2, 284-290.

24.Nuo Duan, Xiaowan Chen, Xianfeng Lin, Dichen Ying, Zhouping Wang, Wenbo Yuan*, Shijia Wu*. Paper-based fluorometric sensing of malachite green using synergistic recognition of aptamer-molecularly imprinted polymers and luminescent metal–organic frameworks. Sensors & Actuators B: Chemical. 2023, 384, 133665.

25.Nuo Duan, Kexin Ren, Chen Lyu, Zhouping Wang, Shijia Wu*. Discovery and Optimization of an Aptamer and Its Sensing Ability to Amantadine Based on SERS via Binary Metal Nanoparticles. Journal of Agricultural and Food Chemistry. 2022, 70, 14805-14815.

1.食品安全危害物适配体SELEX筛选体系及纳米生物界面组装研究，高等学校科学研究优秀成果奖-自然科学奖二等奖，2017，排名第三

2.农产品安全危害物适配体筛选模型及纳米生物传感机制研究，新疆生产建设兵团自然科学奖二等奖，2024，排名第三

3.新型绿色生物农药小盾壳霉的创制及其在防治油菜菌核病的应用，中国商业联合会科学技术奖二等奖，2021，排名第三

4.水产品加工过程中危害物的识别检测与控制技术研发，中国轻工业联合会科技进步奖三等奖，2020，排名第二

1.段诺，齐硕，吴世嘉，王周平，β-乳球蛋白特异性适配体的应用，授权专利号：ZL202310317393.8

2.段诺，宋铭倩，吴世嘉,李昌鑫，王周平，应用比率型荧光适配体传感器检测氯丙嗪的方法，授权专利号：ZL202210570429.9

3.Nuo Duan，Shijia Wu，Shuo Qi，Zhouping Wang，NUCLEIC ACID APTAMER SPECIFICALLY RECOGNIZING β-LACTOGLOBULINAND USE THEREOF，授权专利号：US012152245B2

4.段诺，任柯馨，吴世嘉，常玉婷，陈晓婉，一种特异性识别志贺毒素Ⅱ型B亚基的核酸适配体及其应用，授权专利号：ZL202310683332.3

5.段诺，宋铭倩，吴世嘉，一种特异性结合氯丙嗪的核酸适配体的筛选及应用，授权专利号：ZL202210080261.3

6.段诺，李昌鑫，吴世嘉，一种特异性识别甲氧苄啶的核酸适配体及其筛选和应用，授权专利号：ZL202210048863.0

7.段诺，李昌鑫，吴世嘉，宋铭倩，王周平，特异性识别左旋咪唑的核酸适配体及其双模式纳米探针和应用，授权专利号：ZL202210563028.0

8.段诺，任乐，王周平，吴世嘉，一种具有广谱性识别无环鸟苷类似物能力的核酸适配体，授权专利号：ZL202110143016.8

9.段诺，宋明燕，王周平，吴世嘉，一种特异性识别利巴韦林的适配体序列及其应用，授权专利号：ZL202110165104.8

10.段诺，糜唯钰，吴世嘉，王周平，一种特异识别酪胺的核酸适配体及其应用，授权专利号：ZL201910106599.X

11.段诺，田会丽，吴世嘉，王周平，一组特异识别精胺的寡核苷酸适配体，授权专利号：ZL201910188122.0

12.段诺，吕辰，王周平，吴世嘉，特异性识别金刚烷胺的适配体及其应用，授权专利号：ZL202110150295.0

13.段诺，朱肖音，吴世嘉，王周平，齐硕，一种特异识别组胺的寡核苷酸适配体及其应用，授权专利号：ZL201910121460.2

14.段诺，齐硕，吴世嘉，王周平，一种特异性识别β-乳球蛋白的核酸适配体及其应用，授权专利号：ZL202010094212.6

15.段诺，沈默斐，王周平，吴世嘉，邹颖，一种复合膜传感器及其检测副溶血性弧菌的方法，授权专利号：ZL201810076439.0

《食品安全I》 本科生

《食品分析》 本科生

《食品分析（实验）》 本科生

《食品毒理学》 本科生

《食品质量与安全导论》研究生